Max-Planck-Institut für Informatik
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The Structural Mutation Annotation (StructMAn) server provides the annotation of non-synonymous single-nucleotide polymorphisms (nsSNPs) in the context of the structural neighbourhood of the resulting amino acid variations in the protein. Its rationale is that if a mutation is located on an interaction interface between the protein and another protein, DNA, RNA or a small molecule, it is likely to interfere with this interaction.

Given a set of protein or gene identifiers and a list of nsSNPs, StructMAn searches for all experimentally resolved three-dimensional structures of the corresponding proteins or their homologs, maps the nsSNPs onto them and calculates the distances to the other components of a complex: protein and nucleic acid chains and low molecular-weight ligands. It calculates the interaction score that on a scale from 0 to 1 describes the probability of the given nsSNP to disrupt one of these interactions.

In order to use the server, one has to upload mutation datasets. You can use either the standard VCF files or a list of protein or gene identifiers followed by the description of nsSNP (SMLF format). Additional options include the GO term analysis and the ligand similarity search.

For more information on the computation pipeline, see Documentation. For more information on the input and output formats, see FAQ.