StructMAn
Description
The
Structural
Mutation
Annotation (StructMAn) server provides the annotation of
non-synonymous single-nucleotide polymorphisms (nsSNPs) in the context of the structural neighbourhood of the
resulting amino acid variations in the protein. Its rationale is that if a mutation is located on an interaction
interface between the protein and another protein, DNA, RNA or a small molecule, it is likely to interfere with
this interaction.
Given a set of protein or gene identifiers and a list of nsSNPs, StructMAn searches for all experimentally resolved
three-dimensional structures of the corresponding proteins or their homologs, maps the nsSNPs onto them and calculates
the distances to the other components of a complex: protein and nucleic acid chains and low molecular-weight ligands.
It calculates the interaction score that on a scale from 0 to 1 describes the probability of the given nsSNP to
disrupt one of these interactions.
In order to use the server, one has to
upload mutation datasets.
You can use either the standard
VCF files or a list of protein or
gene identifiers followed by the description of nsSNP (
SMLF format).
Additional options include the
GO term analysis and the
ligand similarity search.
For more information on the computation pipeline, see
Documentation.
For more information on the input and output formats, see
FAQ.
